Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines: Strategies, Technologies, and Applications
- Length: 288 pages
- Edition: 1
- Language: English
- Publisher: Wiley-VCH
- Publication Date: 2021-10-18
- ISBN-10: 352734991X
- ISBN-13: 9783527349913
- Sales Rank: #0 (See Top 100 Books)
Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases
Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease.
Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications
- Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc.
- Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques
- Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines.
Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.
Cover Table of Contents Title Page Copyright Preface 1 Current State of the Art of High‐Throughput Metabolomics 1.1 Introduction 1.2 Metabolomics 1.3 Mass Spectrometry Technology 1.4 Recent Advancements and Applications 1.5 Limitation 1.6 Conclusions and Future Perspectives Acknowledgments References 2 Innovations in Analytical Techniques of Metabolomics 2.1 Introduction 2.2 Current Analytical Technologies of Metabolomics 2.3 Chromatography Platform 2.4 Mass Spectrometry Platform 2.5 Nuclear Magnetic Resonance Platform 2.6 Comprehensive and Multidimensional Analytical Platform 2.7 Conclusions Acknowledgments References 3 Sample Preparation Method for Mass Spectrometry‐Based Metabolomics 3.1 Introduction 3.2 Sample Collection and Storage 3.3 Sample Preparation and Processing 3.4 Application 3.5 Future Development Acknowledgments References 4 Multivariate Data Analysis Approach for Mass Spectrometry‐Based Metabolomics 4.1 Introduction 4.2 Separation‐Based MS Techniques 4.3 Separation‐Free MS Techniques 4.4 Tools for MS Result Analysis 4.5 Multivariate Statistical Analysis Approach for Data Analysis 4.6 Limitations and Challenges 4.7 Conclusions and Future Perspectives Acknowledgments References 5 Mass Spectrometry‐Driven Metabolomics for Metabolites and Metabolic Pathway Analysis 5.1 Introduction 5.2 Mass Spectrometry‐Driven Metabolomics for Biomarker Discovery 5.3 Data Extraction and Analysis for Metabolites and Metabolic Pathway 5.4 Biomarker Identification 5.5 Applications 5.6 Conclusions Acknowledgments References 6 Metabolomics as Drivers for Biomarker Discovery and Mechanism Interpretation 6.1 Introduction 6.2 Metabolomics for Biomarker Discovery 6.3 Metabolomics for Mechanism Interpretation 6.4 Application 6.5 Current Trends and Future Perspectives 6.6 Conclusions Acknowledgments References 7 Current Status of Technical Challenges in Mass Spectrometry‐Driven Metabolomics 7.1 Introduction 7.2 Metabolic Fingerprinting and Profiling 7.3 Non‐targeted or Targeted Metabolomics 7.4 Metabolite Identification Bottleneck 7.5 Quality Control Bottleneck 7.6 Mass Spectrometry Techniques 7.7 Prospects 7.8 Conclusions Acknowledgments References 8 The Application of Metabolomics in Cancer Management 8.1 Introduction 8.2 Epidemiology and Diagnosis 8.3 Prospective Biomarkers 8.4 Metabolomics Screening Biomarkers 8.5 Conclusions and Future Directions Acknowledgments References 9 Metabolomics in Coronary Heart Disease: From Biomarker Identification to Pathomechanism Insights 9.1 Introduction 9.2 Predicament 9.3 Metabolomics for CHD 9.4 Biomarker Dilemma 9.5 Lipid Metabolism 9.6 Treatment of Herbal Medicine 9.7 Conclusions and Future Direction Acknowledgments References 10 Metabolomics Applications in Neurological Disease 10.1 Introduction 10.2 CSF Sampling 10.3 Application of Metabolomics in CNS 10.4 Future Direction 10.5 Conclusions Acknowledgments References 11 Metabolomics Toward Precision Medicine 11.1 Introduction 11.2 Precision Medicine: A New Era of Medicine 11.3 Precision Biomarkers 11.4 Metabolomics as a Powerful Tool for Potential Biomarkers 11.5 Practical Application of Metabolomics 11.6 Precision Medicine for Herbal Medicine 11.7 Conclusions and Future Perspectives Acknowledgments References 12 Mass Spectrometry‐Based Metabolomics Toward Biological Function Analysis 12.1 Introduction 12.2 Current Trend and Challenge of Disease Phenotype 12.3 Advances in Mass Spectrometry Analytic Technique 12.4 Advantages of Mass Spectrometry‐Based Metabolomics 12.5 Mass Spectrometry‐Based Metabolomics for Biological Function 12.6 Limitations of MS‐Based Metabolomics 12.7 Future Perspectives 12.8 Conclusions Acknowledgments References 13 Mass Spectrometry‐Driven Active Ingredients Discovery from Herbal Medicine 13.1 Introduction 13.2 An Overview of Herbal Medicine 13.3 Mass Spectrometry to Identify the Chemical Constituents 13.4 Mass Spectrometry for Constituent Analysis In Vivo 13.5 Mass Spectrometry‐Based Chinmedomics Strategy 13.6 Application 13.7 Conclusions and Future Perspectives Acknowledgments References 14 Metabolomics Application in Herbal Medicine 14.1 Introduction 14.2 Metabolomic Dissection of Herbal Medicine 14.3 Application in Herbal Medicine 14.4 Conclusions Acknowledgments References 15 Mass Spectrometry‐Based Metabolomics Insights into the Mode of Action of Natural Products 15.1 Introduction 15.2 Metabolomics: An Overview 15.3 Superiority of MS‐Based Metabolomics 15.4 Mass Spectrometry Techniques Employed in Metabolomics 15.5 Challenges of Natural Products 15.6 Herbal Ingredients: Current Research and Applications 15.7 MS in Natural Product 15.8 MS‐Based Metabolomics in Bioactive Ingredients 15.9 Conclusions and Future Perspective Acknowledgment References 16 Mass Spectrometry‐Driven Lipidomics for Biomarker, Molecular Mechanism, and Therapy 16.1 Introduction 16.2 Lipidomics Method 16.3 Sample Preparation 16.4 Analytical Techniques in Lipidomics 16.5 Lipidomics for Biomarker Discovery 16.6 Application of MS‐Based Lipidomics 16.7 Future Perspectives 16.8 Conclusions Acknowledgments References 17 Potential Application of Mass Spectrometry‐Based Lipidomics for Herbal Medicine 17.1 Introduction 17.2 Lipidomics Method 17.3 Mass Spectrometry Technique in Lipidomics 17.4 Application of Mass Spectrometry‐Based Lipidomics for Herbal Medicine 17.5 Conclusions Acknowledgments References Index End User License Agreement
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