Magnetic Nanoparticles in Human Health and Medicine: Current Medical Applications and Alternative Therapy of Cancer

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Table of Contents
Magnetic Nanoparticles in Human Health and Medicine
Copyright
List of Contributors
1 An Introduction to Magnetic Nanoparticles
    1.1 Magnetism of Nanoparticles: From Bulk to Nanoscale
    1.2 Magnetic Nanoparticles as a New Tool for Biomedical Applications
    1.3 Conclusion
    References
Part I: Current Biomedical Applications of Magnetic Nanoparticles
    2 Magnetic Nanoparticles in Nanomedicine
        2.1 Introduction
        2.2 Biomedical Applications
        2.3 Conclusions and Final Remarks
        Acknowledgments
        References
    3 Clustering of Magnetic Nanoparticles for Nanomedicine
        3.1 Introduction
        3.2 Clustering Theory
        3.3 Clustering Methods
        3.4 Theranostic Relevant Examples
        3.5 Conclusion and General Remarks
        References
    4 Multifunctional Bioactive Magnetic Scaffolds with Tailored Features for Bone Tissue Engineering
        4.1 Introduction
        4.2 Scaffolds for Bone Tissue Engineering: An Overview
        4.3 Surface Presentation
        4.4 Bioactive Magnetic Scaffolds
        4.5 Conclusions and Final Remarks
        References
    5 Magnetic Nanoparticles in the Development of Polymer Scaffolds for Medical Applications
        5.1 Introduction
        5.2 Production Methods for Scaffolds and Hydrogels Based on Polymer Nanocomposites Filled
        5.3 Applications of Scaffolds Filled with MNPs
        5.4 Conclusion
        References
    6 Magnetic Polymer Colloids for Ultrasensitive Molecular Imaging
        6.1 Introduction
        6.2 Molecular Imaging
        6.3 Development of MRI as a Tool for Ultrasensitive Molecular Imaging
        6.4 Conclusion and Final Remarks
        Acknowledgments
        References
    7 Iron oxide Nanoparticles in Anticancer Drug Delivery and Imaging Diagnostics
        7.1 Introduction
        7.2 SPIONs – Anticancer Drug Delivery
        7.3 SPIONs in Imaging Techniques for Biomedical Applications
        7.4 Conclusion
        References
    8 Functional Addressable Magnetic Domains and Their Potential Applications in Theranostics
        8.1 Introduction
        8.2 Magnetite: The Addressable Compass
        8.3 Magnetite Magnetic Moments
        8.4 Magnetic Domains and Superparamagnetism in Magnetite Nanoparticles (MNPs)
        8.5 SPIONs Synthesis
        8.6 MNPs Functionalization
        8.7 Theranostics: Concepts and Possibilities
        8.8 Conclusion
        References
    9 Nuclear/MR Magnetic Nanoparticle‐based Probes for Multimodal Biomedical Imaging
        9.1 Introduction
        9.2 Overview of Imaging Techniques
        9.3 SPECT/PET/MRI Tracers
        9.4 Conclusion and Final Remarks
        References
Part II: Magnetic Nanoparticles in Alternative Cancer Therapy
    10 Magnetic Nanoparticles Hyperthermia
        10.1 Introduction
        10.2 Synthesis Methods
        10.3 In Vitro/In Vivo and Preclinical MNH Research
        10.4 State‐of‐the‐Art of MNH
        10.5 Conclusion
        References
    11 Drug Delivery and Magnetic Hyperthermia Based on Surface Engineering of Magnetic Nanoparticles
        11.1 Introduction
        11.2 Magnetic Properties of Iron Oxide Nanoparticles
        11.3 Surface Engineering of MNP
        11.4 Surface Engineering of MNP in Magnetic Properties and Colloidal Stability
        11.5 Surface Engineering of MNP in Drug Delivery and Magnetic Hyperthermia
        11.6 MNP Surface Engineering for Drug Delivery: Hydrophobic Medicines
        11.7 Conclusion and Outlook
        References
    12 Improving Magneto‐thermal Energy Conversion Efficiency of Magnetic Fluids Through External DC Magnetic Field Induced Orientational Ordering
        12.1 Introduction
        12.2 Linear Response Model for RFAMF‐Induced Heating of Magnetic Nanofluids
        12.3 Effect of Medium Viscosity on RFAMF Induced Heating Efficiency
        12.4 External DC Magnetic Field‐Induced Orientational Ordering
        12.5 Experimental Determination of RFAMF‐Induced Heating Efficiency
        12.6 Enhancement of Heating Efficiency upon Orientational Ordering
        12.7 Conclusion and Final Remarks
        References
    13 Classical Magnetoliposomes vs. Current Magnetocyclodextrins with Ferrimagnetic Nanoparticles for High Efficiency and Low Toxicity in Noninvasive Alternative Therapy of Cancer by Magnetic/Superparamagnetic Hyperthermia
        13.1 Introduction
        13.2 Basic Physical Aspects That Lead to the Heating of MNPs
        13.3 MNPs – Liposomes/ CDs as High Potential in Cancer Therapy by Magnetic/Superparamagnetic Hyperthermia
        13.4 Specific Absorption Rate in SPMHT Using MLPs and MCDs
        13.5 Conclusion
        Acknowledgments
        References
    14 Efficiency of Energy Dissipation in Nanomagnets: A Theoretical Study of AC Susceptibility
        14.1 Introduction
        14.2 General Formalism: The SAR in Terms of the Dynamic Susceptibility
        14.3 Linear and Nonlinear Susceptibility: Study of Two System Examples
        14.4 Conclusion
        References
        Note
    15 Magnetic Nanoparticle Relaxation in Biomedical Application: Focus on Simulating Nanoparticle Heating
        15.1 Introduction
        15.2 Theory of Magnetic Particle Heating
        15.3 Predicting the Magnetic Particle Heating
        15.4 Conclusion
        Appendix
        Acknowledgments
        References
        Notes
    16 Magnetic Nanoparticles in Alternative Tumors Therapy: Biocompatibility, Toxicity, and Safety Compared with Classical Methods
        16.1 Introduction
        16.2 Biocompatibility, Toxicity, and Safety of Magnetic Nanoparticles for Alternative Cancer Therapy
        16.3 Conclusion
        References
        Note
    17 The Size, Shape, and Composition Design of Iron Oxide Nanoparticles to Combine, MRI, Magnetic Hyperthermia, and Photothermia
        17.1 Introduction
        17.2 Structure, Magnetic Properties and Synthesis Methods of Iron Oxide NPs
        17.3 Iron Oxide as Contrast Agent for MRI
        17.4 Magnetic Hyperthermia with Iron Oxide NPs
        17.5 Iron Oxide Nanoparticles Used for Photothermal Treatment
        17.6 Conclusion and Final Remarks
        References
    18 Magnetic/Superparamagnetic Hyperthermia in Clinical Trials for Noninvasive Alternative Cancer Therapy
        18.1 Introduction
        18.2 Magnetic/Superparamagnetic Hyperthermia in Clinical Trials
        18.3 Increase Efficacy of MHT/SPMHT in Cancer Treatment by Using Dual‐Therapy
        18.4 Conclusions
        Acknowledgments
        References
Index
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